{"id":3018,"date":"2022-01-20T13:41:11","date_gmt":"2022-01-20T04:41:11","guid":{"rendered":"http:\/\/shimane-univ-biochemistry.jp\/?p=3018"},"modified":"2022-03-31T11:38:13","modified_gmt":"2022-03-31T02:38:13","slug":"%ef%bc%bb%e8%ab%96%e6%96%87%e7%99%ba%e8%a1%a8%ef%bc%bd%e7%aa%92%e7%b4%a0%e6%ac%a0%e4%b9%8f%e6%9d%a1%e4%bb%b6%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8b%e3%82%a2%e3%82%b9%e3%82%b3%e3%83%ab%e3%83%93%e3%83%b3","status":"publish","type":"post","link":"https:\/\/shimane-univ-biochemistry.jp\/?p=3018","title":{"rendered":"\uff3b\u8ad6\u6587\u767a\u8868\uff3d\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u306b\u304a\u3051\u308b\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u4ee3\u8b1d\u306e\u6d3b\u6027\u5316\u3068\u610f\u7fa9@BBB\u8a8c"},"content":{"rendered":"<p><span style=\"font-size: 14pt;\"><strong><span style=\"font-family: 'comic sans ms', sans-serif;\">2022\u5e741\u670813\u65e5<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'comic sans ms', sans-serif;\">\u3000\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u306b\u304a\u3051\u308b\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u4ee3\u8b1d\u306e\u6d3b\u6027\u5316\u3068\u305d\u306e\u610f\u7fa9\u306b\u95a2\u3059\u308b<span style=\"color: #3366ff;\"><a style=\"color: #3366ff;\" href=\"http:\/\/shimane-univ-biochemistry.jp\/?page_id=69\">\u4e38\u7530\u30b0\u30eb\u30fc\u30d7<\/a><\/span>\u306e\u7814\u7a76\uff08\u5ca9\u4e0a\u304f\u3093\u306e\u4fee\u58eb\u8ad6\u6587\u7814\u7a76\uff09\u304cBBB\u8a8c\u306b\u53d7\u7406\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/p>\n<p style=\"padding-left: 40px;\"><span style=\"font-size: 12pt;\"><span style=\"font-family: 'comic sans ms', sans-serif;\"><span style=\"color: #008000;\"><strong>Activation of ascorbate metabolism by nitrogen starvation and its physiological impacts in <\/strong><\/span><em><span style=\"color: #008000;\"><strong>Arabidopsis thaliana<\/strong><\/span><br \/>\n<\/em><\/span><span style=\"font-family: 'comic sans ms', sans-serif;\">Takumi Iwagami, Takahisa Ogawa, Takahiro Ishikawa, Takanori Maruta<sup>*<br \/>\n<\/sup><\/span><span style=\"font-family: 'comic sans ms', sans-serif;\"><strong><em>Bioscience, Biotechnology, and Biochemistry<\/em><\/strong>, 86: 476-489, 2022. DOI: <span style=\"color: #3366ff;\"><a style=\"color: #3366ff;\" href=\"https:\/\/doi.org\/10.1093\/bbb\/zbac010\">doi.org\/10.1093\/bbb\/zbac010<\/a><\/span>\u00a0(<sup>*<\/sup>corresponding author)<\/span><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 14pt; font-family: 'comic sans ms', sans-serif;\">\uff3b\u7814\u7a76\u5185\u5bb9\uff3d<\/span><\/p>\n<p><span style=\"font-size: 14pt; font-family: 'comic sans ms', sans-serif;\">1. \u80cc\u666f<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'comic sans ms', sans-serif;\">\u3000\u6d3b\u6027\u9178\u7d20\u7a2e\uff08ROS\uff09\u306f\u7d30\u80de\u6bd2\u6027\u4f5c\u7528\u3068\u30b7\u30b0\u30ca\u30eb\u6a5f\u80fd\u3092\u4f75\u305b\u6301\u3064\u305f\u3081\u3001\u305d\u306e\u91cf\u7684\u30d0\u30e9\u30f3\u30b9\u306e\u5236\u5fa1\u306f\u690d\u7269\u306e\u751f\u5b58\u3084\u767a\u9054\u306b\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002\u74b0\u5883\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u306fROS\u306e\u751f\u6210\u91cf\u304c\u5897\u5927\u3059\u308b\u305f\u3081\u3001\u305d\u306e\u4f5c\u7528\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3066\u3057\u307e\u3044\u3001\u9178\u5316\u640d\u50b7\u304c\u751f\u3058\u307e\u3059\u3002\u3053\u308c\u3092\u9632\u3050\u306e\u304c\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u6297\u9178\u5316\u30b7\u30b9\u30c6\u30e0\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u5149\u3084\u6e29\u5ea6\u3001\u6c34\u5206\u5909\u5316\u306a\u3069\u306e\u975e\u751f\u7269\u7684\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u306b\u304a\u3051\u308b\u6297\u9178\u5316\u30b7\u30b9\u30c6\u30e0\u306e\u5236\u5fa1\u3084\u91cd\u8981\u6027\u306f\u6df1\u304f\u8abf\u3079\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u81ea\u7136\u754c\u3067\u8d77\u3053\u308b\u6804\u990a\u7d20\u306e\u6b20\u4e4f\u3084\u4ed6\u306e\u30b9\u30c8\u30ec\u30b9\u3068\u306e\u8907\u5408\u6761\u4ef6\u3067\u306f\u3042\u307e\u308a\u8abf\u3079\u3089\u308c\u3066\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u672c\u7814\u7a76\u3067\u306f\u3001\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306b\u304a\u3051\u308b\u6804\u990a\u6b20\u4e4f\u304c\u6297\u9178\u5316\u30b7\u30b9\u30c6\u30e0\u306b\u53ca\u307c\u3059\u5f71\u97ff\u3092\u8abf\u3079\u308b\u3068\u3068\u3082\u306b\u3001\u305d\u306e\u751f\u7406\u5b66\u7684\u610f\u7fa9\u3092\u9006\u907a\u4f1d\u5b66\u7684\u306b\u89e3\u6790\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 14pt; font-family: 'comic sans ms', sans-serif;\">2. \u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u4ee3\u8b1d\u306f\u7a92\u7d20\u6b20\u4e4f\u306b\u3088\u308a\u6d3b\u6027\u5316\u3055\u308c\u308b<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'comic sans ms', sans-serif;\">\u3000\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u3092\u7a92\u7d20\u3001\u30ea\u30f3\u3001\u786b\u9ec4\u307e\u305f\u306f\u30ab\u30ea\u30a6\u30e0\u306e\u6b20\u4e4f\u57f9\u5730\u3067\u751f\u80b2\u3055\u305b\u3001\u6297\u9178\u5316\u5264\u30ec\u30d9\u30eb\u304a\u3088\u3073\u6297\u9178\u5316\u9175\u7d20\u6d3b\u6027\u3078\u306e\u5f71\u97ff\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u5b9f\u9a13\u3067\u306f\u3001\u5404\u6804\u990a\u7d20\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e1\/10\u91cf\u307e\u3067\u4f4e\u4e0b\u3055\u305b\u305f\u57f9\u5730\u3092\u7528\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u6761\u4ef6\u3067\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306b\u542b\u307e\u308c\u308b\u6804\u990a\u7d20\u91cf\u3092\u4eca\u56de\u306f\u8abf\u3079\u3066\u3044\u306a\u3044\u306e\u3067\u3001\u5b9f\u969b\u306b\u6804\u990a\u6b20\u4e4f\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u304b\u306f\u78ba\u8a8d\u3067\u304d\u3066\u3044\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u6761\u4ef6\u3068\u6bd4\u8f03\u3057\u3066\u3001\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u306e\u8449\u3067\u306f\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u542b\u91cf\u304c\u6709\u610f\u306b\u9ad8\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u30011\uff09\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u4f9d\u5b58\u7684\u306aH<sub>2<\/sub>O<sub>2<\/sub>\u6d88\u53bb\u53cd\u5fdc\u3092\u89e6\u5a92\u3059\u308b\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u30da\u30eb\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\uff08APX\uff09\u306e\u6d3b\u6027\u3068\u30012\uff09APX\u53cd\u5fdc\u306b\u3088\u3063\u3066\u9178\u5316\u3055\u308c\u305f\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u3092\u9084\u5143\u578b\u306b\u518d\u751f\u3059\u308b\u30c7\u30d2\u30c9\u30ed\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u9084\u5143\u9175\u7d20\uff08DHAR\uff09\u306e\u6d3b\u6027\u3082\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u3067\u9ad8\u307e\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u5b9a\u91cf\u7684RT-PCR\u306e\u7d50\u679c\u304b\u3089\u3001APX\u304a\u3088\u3073DHAR\u306e\u6d3b\u6027\u5316\u306f\u3001\u7d30\u80de\u8cea\u578b\u30a2\u30a4\u30bd\u30d5\u30a9\u30fc\u30e0\u306e\u767a\u73fe\u8a98\u5c0e\u306b\u8d77\u56e0\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u4ee3\u8b1d\u3068\u306f\u5bfe\u7167\u7684\u306b\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u306e\u4e3b\u8981H<sub>2<\/sub>O<sub>2<\/sub>\u6d88\u53bb\u9175\u7d20\u30fb\u30ab\u30bf\u30e9\u30fc\u30bc\uff08CAT\uff09\u306e\u6d3b\u6027\u306f\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u3067\u4f4e\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002CAT\u306e\u6d3b\u6027\u4f4e\u4e0b\u306b\u3088\u308a\u3001\u30da\u30eb\u30aa\u30ad\u30b7\u30bd\u30fc\u30e0\u304b\u3089\u7d30\u80de\u8cea\u3078\u306eH<sub>2<\/sub>O<sub>2<\/sub>\u6f0f\u6d29\u304c\u8d77\u3053\u308b\u3068\u4e88\u60f3\u3055\u308c\u308b\u305f\u3081\u3001\u7d30\u80de\u8cea\u578bAPX\u304a\u3088\u3073DHAR\u306e\u6d3b\u6027\u5316\u306fCAT\u6d3b\u6027\u3092\u88dc\u3046\u305f\u3081\u306e\u5fdc\u7b54\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u306b\u304a\u3051\u308b\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u4ee3\u8b1d\u306e\u6d3b\u6027\u5316\u306f\u7d30\u80de\u5185\u30ec\u30c9\u30c3\u30af\u30b9\u72b6\u614b\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span><\/p>\n<p><a href=\"https:\/\/shimane-univ-biochemistry.jp\/wp-content\/uploads\/2022\/01\/\u3055\u3055\u3055\u3055-scaled.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-3222 size-full\" src=\"https:\/\/shimane-univ-biochemistry.jp\/wp-content\/uploads\/2022\/01\/\u3055\u3055\u3055\u3055-scaled-e1647926745153.jpg\" alt=\"\" width=\"1500\" height=\"1208\" \/><\/a><\/p>\n<p><span style=\"font-size: 14pt; font-family: 'comic sans ms', sans-serif;\">3. \u7a92\u7d20\u6b20\u4e4f\u306b\u3088\u308a\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u6b20\u4e4f\u5909\u7570\u682a\u306f\u3080\u3057\u308d\u5f37\u304f\u306a\u308b\uff1f<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'comic sans ms', sans-serif;\">\u3000\u6b21\u306b\u3001\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u306b\u304a\u3051\u308b\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u306e\u751f\u7406\u5b66\u7684\u91cd\u8981\u6027\u3092\u8abf\u3079\u308b\u76ee\u7684\u3067\u3001\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u6b20\u4e4f\u5909\u7570\u682a\uff08<em>vtc2<\/em>\uff09\u3092\u7528\u3044\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u57f9\u5730\u30d7\u30ec\u30fc\u30c8\u3084\u6c34\u8015\u683d\u57f9\u30b7\u30b9\u30c6\u30e0\u3092\u7528\u3044\u305f\u7a92\u7d20\u6b20\u4e4f\u5b9f\u9a13\u306e\u7d50\u679c\u3001\u91ce\u751f\u682a\u3068<em>vtc2<\/em>\u306e\u8868\u73fe\u578b\u306b\u660e\u78ba\u306a\u9055\u3044\u306f\u307f\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u7a92\u7d20\u6b20\u4e4f\u3068\u5f37\u5149\u30b9\u30c8\u30ec\u30b9\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u306b\u3057\u307e\u3057\u305f\u3002\u5f37\u5149\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u3067\u306f\u5149\u5408\u6210\u96fb\u5b50\u4f1d\u9054\u7cfb\u304c\u30d1\u30f3\u30af\u3057\u3066\u3057\u307e\u3044\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u5927\u91cf\u306eROS\u304c\u751f\u6210\u3055\u308c\u307e\u3059\u3002\u7a92\u7d20\u6b20\u4e4f\u3082\u5149\u5408\u6210\u306b\u5bfe\u3057\u3066\u6291\u5236\u7684\u306b\u306f\u305f\u3089\u304f\u3053\u3068\u304b\u3089\u3001\u3053\u308c\u3089\u306e\u30b9\u30c8\u30ec\u30b9\u306e\u8907\u5408\u306b\u3088\u3063\u3066\u9855\u8457\u306a\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u304c\u751f\u3058\u308b\u306f\u305a\u3067\u3059\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u304b\u3089\u3001<em>vtc2<\/em>\u5909\u7570\u682a\u306f\u5f37\u5149\u30b9\u30c8\u30ec\u30b9\u306b\u5f31\u304f\u3001\u660e\u78ba\u306a\u7d30\u80de\u6b7b\u306e\u8868\u73fe\u578b\u3092\u793a\u3059\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u306e\u3067\u3001\u7a92\u7d20\u6b20\u4e4f\u3068\u5f37\u5149\u306e\u8907\u5408\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u3067\u306f\u3001\u3088\u308a\u660e\u78ba\u306a\u7d30\u80de\u6b7b\u304c\u8d77\u3053\u308b\u3068\u4e88\u60f3\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'comic sans ms', sans-serif;\">\u3000\u7a92\u7d20\u5341\u5206\u6761\u4ef6\u3067\u5f37\u5149\u3092\u7167\u5c04\u3057\u305f\u5834\u5408\u3001<em>vtc2<\/em>\u5909\u7570\u682a\u3067\u306f\u660e\u78ba\u306a\u7d30\u80de\u6b7b\u304c\u8d77\u3053\u308a\u307e\u3057\u305f\u304c\u3001\u91ce\u751f\u682a\u3067\u306f\u8996\u899a\u7684\u306a\u30c0\u30e1\u30fc\u30b8\u306f\u89b3\u5bdf\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u3001\u5f37\u5149\u4e0b\u306e<em>vtc2<\/em>\u5909\u7570\u682a\u3067\u751f\u3058\u308b\u7d30\u80de\u6b7b\u306f\u3001\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u3067\u306f\u5b8c\u5168\u306b\u6d88\u5931\u3057\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u7a92\u7d20\u6b20\u4e4f\u304a\u3088\u3073\u5f37\u5149\u306e\u8907\u5408\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u3067\u306f\u91ce\u751f\u682a\u3068<em>vtc2<\/em>\u5909\u7570\u682a\u306e\u8868\u73fe\u578b\u306b\u9055\u3044\u304c\u306a\u304f\u306a\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u8907\u5408\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u3067\u306f\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u84c4\u7a4d\u304c\u9855\u8457\u306b\u306a\u308a\u3001\u8449\u304c\u9ed2\u305a\u3093\u3067\u3057\u307e\u3046\u305f\u3081\u3001\u7d30\u80de\u6b7b\u304c\u8996\u899a\u7684\u306b\u898b\u3048\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u30c8\u30ea\u30d1\u30f3\u30d6\u30eb\u30fc\u67d3\u8272\u306b\u3088\u3063\u3066\u7d30\u80de\u6b7b\u3092\u53ef\u8996\u5316\u3057\u305f\u7d50\u679c\u3001\u3084\u306f\u308a\u7a92\u7d20\u5341\u5206\u6761\u4ef6\u3067\u5f37\u5149\u3092\u7167\u5c04\u3057\u305f\u5834\u5408\u306b\u751f\u3058\u308b<em>vtc2<\/em>\u5909\u7570\u682a\u306e\u7d30\u80de\u6b7b\u306e\u8868\u73fe\u578b\u304c\u3001\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u3067\u306f\u8d77\u3053\u3089\u306a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'comic sans ms', sans-serif;\">\u3000\u4e00\u65b9\u3067\u3001\u5149\u5408\u6210\u306e\u30c0\u30e1\u30fc\u30b8\u306e\u6307\u6a19\u3067\u3042\u308b\u5149\u5316\u5b66\u7cfbII\u306e\u6700\u5927\u91cf\u5b50\u53ce\u7387\uff08Fv\/Fm\uff09\u3092\u6e2c\u5b9a\u3057\u305f\u3068\u3053\u308d\u3001\u91ce\u751f\u682a\u3068<em>vtc2<\/em>\u5909\u7570\u682a\u306e\u4e21\u65b9\u3067\u3001\u5149\u5408\u6210\u306e\u30c0\u30e1\u30fc\u30b8\u306f\u5f37\u5149\u5358\u72ec\u3088\u308a\u3082\u7a92\u7d20\u6b20\u4e4f\u3068\u306e\u8907\u5408\u306b\u3088\u3063\u3066\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u3001\u5f37\u5149\u5358\u72ec\u306e\u5834\u5408\u3001<em>vtc2<\/em>\u5909\u7570\u682a\u306eFv\/Fm\u5024\u306f\u91ce\u751f\u682a\u3088\u308a\u3082\u4f4e\u304f\u306a\u308a\u307e\u3059\u304c\u3001\u8907\u5408\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u3067\u306f\u682a\u9593\u3067\u306e\u5dee\u304c\u6d88\u5931\u3057\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u7a92\u7d20\u6b20\u4e4f\u306f<em>vtc2<\/em>\u5909\u7570\u682a\u306b\u30d7\u30e9\u30a4\u30df\u30f3\u30b0\u52b9\u679c\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u3067\u3001<em>vtc2<\/em>\u5909\u7570\u682a\u306e\u30b9\u30c8\u30ec\u30b9\u8010\u6027\u80fd\u304c\u91ce\u751f\u682a\u30ec\u30d9\u30eb\u306b\u307e\u3067\u9ad8\u3081\u3089\u308c\u3001\u305d\u306e\u7d50\u679c\u3068\u3057\u3066\u7d30\u80de\u6b7b\u304c\u6d88\u5931\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3064\u307e\u308a\u3001\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u6b20\u4e4f\u3092\u88dc\u3046\u4f55\u3089\u304b\u306e\u30b7\u30b9\u30c6\u30e0\u304c\u7a92\u7d20\u6b20\u4e4f\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u3055\u3089\u306a\u308b\u89e3\u6790\u306e\u7d50\u679c\u3001\u305d\u306e\u76f8\u88dc\u30b7\u30b9\u30c6\u30e0\u306f\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><a href=\"https:\/\/shimane-univ-biochemistry.jp\/wp-content\/uploads\/2022\/01\/121.jpg\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-3219 size-full\" src=\"https:\/\/shimane-univ-biochemistry.jp\/wp-content\/uploads\/2022\/01\/121-e1647926762170.jpg\" alt=\"\" width=\"1500\" height=\"1351\" \/><\/a><\/p>\n<p><span style=\"font-size: 14pt; font-family: 'comic sans ms', sans-serif;\">4. \u7d50\u8ad6<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'comic sans ms', sans-serif;\">\u3000\u4eca\u56de\u306e\u7814\u7a76\u304b\u3089\u3001\u30b7\u30ed\u30a4\u30cc\u30ca\u30ba\u30ca\u306b\u304a\u3044\u3066\u7a92\u7d20\u6b20\u4e4f\u306b\u3088\u308a\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u4ee3\u8b1d\u304c\u6d3b\u6027\u5316\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u304a\u305d\u3089\u304f\u3001\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u3067\u8d77\u3053\u308b\u30ab\u30bf\u30e9\u30fc\u30bc\u6d3b\u6027\u306e\u4f4e\u4e0b\u3092\u88dc\u3046\u4ed5\u7d44\u307f\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4e00\u65b9\u3067\u3001\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u306b\u304a\u3051\u308b<em>vtc2<\/em>\u5909\u7570\u682a\u306e\u751f\u80b2\u3084\u8868\u73fe\u578b\u306f\u91ce\u751f\u682a\u3068\u307e\u3063\u305f\u304f\u5909\u308f\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u308c\u3069\u3053\u308d\u304b\u7a92\u7d20\u6b20\u4e4f\u3068\u5f37\u5149\u30b9\u30c8\u30ec\u30b9\u3092\u7d44\u307f\u5408\u308f\u305b\u305f\u7d50\u679c\u3001\u5f37\u5149\u306e\u5358\u72ec\u51e6\u7406\u306b\u3088\u3063\u3066<em>vtc2<\/em>\u3067\u751f\u3058\u308b\u9855\u8457\u306a\u7d30\u80de\u6b7b\u304c\u3001\u5f37\u5149\u3068\u7a92\u7d20\u6b20\u4e4f\u306e\u8907\u5408\u7684\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u306f\u8d77\u3053\u3089\u306a\u3044\u3068\u3044\u3046\u8208\u5473\u6df1\u3044\u73fe\u8c61\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u4ee3\u8b1d\u306e\u6d3b\u6027\u5316\u306f\u7a92\u7d20\u6b20\u4e4f\u4e0b\u3067\u306e\u7d30\u80de\u5185\u30ec\u30c9\u30c3\u30af\u30b9\u72b6\u614b\u306e\u7dad\u6301\u306b\u5bc4\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u304c\u3001\u3053\u306e\u4ed5\u7d44\u307f\u3092\u3055\u3089\u306b\u88dc\u3046\u9632\u5fa1\u6a5f\u69cb\u306e\u5b58\u5728\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002\u4eca\u5f8c\u3001\u3053\u306e\u4ee3\u66ff\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u690d\u7269\u306e\u30b9\u30c8\u30ec\u30b9\u9632\u5fa1\u6a5f\u69cb\u304c\u3088\u308a\u6df1\u3044\u30ec\u30d9\u30eb\u3067\u660e\u3089\u304b\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 14pt; font-family: 'comic sans ms', sans-serif;\">5. \u601d\u3044\u51fa<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'comic sans ms', sans-serif;\">\u3000\u672c\u7814\u7a76\u306f\u3001\u5ca9\u4e0a\u62d3\u5df1\u304f\u3093\uff08\u73feM2\uff09\u306e\u4fee\u58eb\u8ad6\u6587\u7814\u7a76\u306e\u4e00\u74b0\u3068\u3057\u3066\u884c\u3063\u305f\u3082\u306e\u3067\u3059\u3002\u4e38\u7530\u30b0\u30eb\u30fc\u30d7\u3068\u3057\u3066\u521d\u3081\u3066\u6804\u990a\u6b20\u4e4f\u30b9\u30c8\u30ec\u30b9\u306b\u30d5\u30a9\u30fc\u30ab\u30b9\u3057\u305f\u7814\u7a76\u3067\u3001\u307e\u305f\u9593\u53e3\u304c\u5e83\u304c\u3063\u305f\u6c17\u304c\u3057\u3066\u5b09\u3057\u3044\u3067\u3059\u3002\u3068\u306f\u3044\u3048\u3001\u50d5\u305f\u3061\u306f\u6804\u990a\u6b20\u4e4f\u51e6\u7406\u306e\u6642\u70b9\u304b\u3089\u30c9\u7d20\u4eba\u3060\u3063\u305f\u305f\u3081\u306b\u3001<em>in vitro<\/em>\u304a\u3088\u3073<em>in vivo<\/em>\u306e\u6804\u990a\u6b20\u4e4f\u6761\u4ef6\u306e\u78ba\u7acb\u3068\u3082\u306b\u6700\u521d\u306f\u5927\u5909\u82e6\u52b4\u3057\u307e\u3057\u305f\u3002\u4e38\u7530\u30b0\u30eb\u30fc\u30d7\u53f2\u4e0a\u6700\u9ad8\u306e\u982d\u8133\u3092\u6301\u3064\u5ca9\u4e0a\u304f\u3093\u3058\u3083\u306a\u304b\u3063\u305f\u3089\u3001\u3082\u306f\u3084\u9014\u4e2d\u3067\u6295\u3052\u3066\u3044\u305f\u3068\u601d\u3044\u307e\u3059\u3002\u5b9f\u9a13\u6761\u4ef6\u306e\u78ba\u7acb\u306b\u306f\u3001\u7a92\u7d20\u5fdc\u7b54\u306e\u30d7\u30ed\u30d5\u30a7\u30c3\u30b7\u30e7\u30ca\u30eb\u3053\u3068\u8702\u8c37\u5353\u58eb\u5148\u751f\u306b\u3082\u305f\u304f\u3055\u3093\u30a2\u30c9\u30d0\u30a4\u30b9\u3092\u3044\u305f\u3060\u3044\u3066\u52a9\u3051\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3057\u305f\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt; font-family: 'comic sans ms', sans-serif;\">\u3000\u4eca\u56de\u306e\u7814\u7a76\u3067\u4e00\u756a\u9a5a\u3044\u305f\u306e\u306f\u3001<em>vtc2<\/em>\u5909\u7570\u682a\u306e\u5f37\u5149\u611f\u53d7\u6027\u304c\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u3067\u56de\u5fa9\u3059\u308b\u3068\u3044\u3046\u8d85\u4e0d\u601d\u8b70\u73fe\u8c61\u3067\u3059\u3002\u690d\u7269\u306f\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\u306e\u6b20\u4e4f\u3059\u3089\u88dc\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u4ed5\u7d44\u307f\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002\u7814\u7a76\u3059\u308c\u3070\u3059\u308b\u307b\u3069\u3001\u690d\u7269\u306e\u9811\u5065\u3055\u3001\u3057\u305f\u305f\u304b\u3055\u304c\u898b\u3048\u3066\u304d\u307e\u3059\u3002\u305d\u3057\u3066\u305d\u308c\u3053\u305d\u304c\u3001\u690d\u7269\u306e\u751f\u304d\u3066\u3044\u308b\u74b0\u5883\u306e\u904e\u9177\u3055\u3092\u7269\u8a9e\u3063\u3066\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u3068\u306f\u3044\u3048\u3001\u306a\u305c\u305d\u306e\u4e0d\u601d\u8b70\u73fe\u8c61\u304c\u7a92\u7d20\u6b20\u4e4f\u6761\u4ef6\u3067\u306e\u307f\u8d77\u3053\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u3000\u306a\u305c\u5f37\u5149\u5358\u72ec\u306e\u6761\u4ef6\u3067\u306f\u8d77\u3053\u3089\u306a\u3044\u306e\u304b\uff1f\u3000\u307e\u3060\u307e\u3060\u8208\u5473\u6df1\u3044\u8b0e\u304c\u6b8b\u3063\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u5ca9\u4e0a\u304f\u3093\u3068\u5f8c\u8f29\u306e\u4f50\u3005\u6728\u304f\u3093\u3068\u4e00\u7dd2\u306b\u3053\u306e\u8b0e\u306b\u6311\u6226\u3057\u3066\u3044\u308b\u3068\u3053\u308d\u3067\u3059\u304c\u3001\u4eca\u56de\u306e\u7814\u7a76\u306e\u30e1\u30a4\u30f3\u30b9\u30c8\u30fc\u30ea\u30fc\u304b\u3089\u5c11\u3057\u9038\u8131\u3059\u308b\u5185\u5bb9\u306b\u306a\u308a\u305d\u3046\u306a\u306e\u3067\u3001\u3053\u3053\u307e\u3067\u306e\u7814\u7a76\u6210\u679c\u306e\u4e00\u90e8\u3092\u4eca\u56de\u306e\u8ad6\u6587\u3068\u3057\u3066\u307e\u3068\u3081\u308b\u306b\u81f3\u308a\u307e\u3057\u305f\u3002\u7d9a\u7de8\u306e\u7814\u7a76\u3082\u304b\u306a\u308a\u9762\u767d\u304f\u306a\u308a\u305d\u3046\u306a\u306e\u3067\u3054\u671f\u5f85\u304f\u3060\u3055\u3044\u3002\u307e\u305f\u65b0\u3057\u3044\u30de\u30c8\u30ea\u30af\u30b9\u304c\u958b\u304d\u305d\u3046\u3067\u3059\u3002\u3075\u3075\u3075\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<div 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