Publications Takahiro ISHIKAWA

［Original Articles, Reviews and Book Chapters/ 原著論文、総説および著書］
　† Equal contribution; * Corresponding author

  1. Maruta T*, Tanaka Y, Yamamoto K, Ishida T, Hamada A and Ishikawa T (Review)
    Evolutionary insights into strategy shifts for the safe and effective accumulation of ascorbate in plants. 
    Journal of Experimental Botany, in press, 2024. DOI: https://doi.org/10.1093/jxb/erae062
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  2. Yoshimura K and Ishikawa T* (Review)
    Physiological function and regulation of ascorbate peroxidase isoforms. 
    Journal of Experimental Botany, in press, 2024. DOI: https://doi.org/10.1093/jxb/erae061
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  3. Ishida T, Tanaka Y, Maruta T, Ishikawa T* (Original Article)
    The D-mannose/L-galactose pathway plays a predominant role in ascorbate biosynthesis in the liverwort Marchantia polymorpha but is not regulated by light and oxidative stress.
    The Plant Journal, 117: 805-817, 2024 Feb. DOI: https://doi.org/10.1111/tpj.16530
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  4. Hamada A, Ishikawa T and Maruta T* (Original Article)
    The demand for ascorbate recycling capacity rises as the ascorbate pool size increases in Arabidopsis plants
    Bioscience, Biotechnology, and Biochemistry, 87: 1332-1335, 2023 Nov. DOI: https://doi.org/10.1093/bbb/zbad107
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  5. Hamada A, Tanaka Y, Ishikawa T and Maruta T* (Original Article)
    Chloroplast dehydroascorbate reductase and glutathione cooperatively determine the capacity for ascorbate accumulation under photooxidative stress conditions
    The Plant Journal, 114: 68-82, 2023 Apr. DOI: https://doi.org/10.1111/tpj.16117
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  6. Tamaki S, Koshitsuka Y, Miyamoto K, Ishikawa T, Shinomura T* (Original Article)
    Chemical and genetic carotenoid deficiency delays growth in dark-grown Euglena gracilis
    Bioscience, Biotechnology, and Biochemistry, 87: 491-500, 2023 Apr. DOI: https://doi.org/10.1093/bbb/zbad024
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  7. Ebenezer TE*, Low RS, O'Neill EC, Huang I, DeSimone A, Farrow SC, Field RA, Ginger ML*, Guerrero SA, Hammond M, Hampl V, Horst G, Ishikawa T, Karnkowska A, Linton EW, Myler P, Nakazawa M, Cardol P, Sánchez-Thomas R, Saville BJ, Shah MR, Simpson AGB, Sur A, Suzuki K, Tyler KM, Zimba PV, Hall N*, Field MC* (Special Article)
    Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world
    Biology Open, 11:  bio059561, 2022 Nov. DOI: https://doi.org/10.1242/bio.059561
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  8. Tanaka Y, Goto K, Jun L, Nishino K, Ogawa T, Maruta T and Ishikawa T* (Original Article)
    Identification of glucanases and phosphorylases involved in hypoxic paramylon degradation in Euglena gracilis. 
    Algal Research, 67: 102829, 2022 Sep. DOI: https://doi.org/10.1016/j.algal.2022.102829
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  9. Maruta T* and Ishikawa T (Book Chapter)
    Analysis of Ascorbate Metabolism in Arabidopsis Under High-Light Stress. 
    In: Mhamdi A (eds) Reactive Oxygen Species in Plants. Methods in Molecular Biology, vol 2526, pp15-24, 2022 Jun. Humana, New York. DOI: 10.1007/978-1-0716-2469-2_2
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  10. Iwagami T, Ogawa T, Ishikawa T and Maruta T* (Original Article)
    Activation of ascorbate metabolism by nitrogen starvation and its physiological impacts in Arabidopsis thaliana.
    Bioscience, Biotechnology, and Biochemistry, 86: 476-489, 2022 Apr. DOI: doi.org/10.1093/bbb/zbac010
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  11. Tamaki S, Sato R, Koshitsuka Y, Asahina M, Kodama Y, Ishikawa T, Shinomura T* (Original Article)
    Suppression of the lycopene cyclase gene causes downregulation of ascorbate peroxidase activity and decreased glutathione pool size, leading to H2O2 accumulation in Euglena gracilis. 
    Frontiers in Plant Science, 12: 786208, 2021 Dec. DOI: doi.org/10.3389/fpls.2021.786208
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  12. Sodeyama T†, Nishikawa H†, Harai K†, Takeshima D, Sawa Y, Maruta T and Ishikawa T* (Original Article)
    The D-mannose/L-galactose pathway is the dominant ascorbate biosynthetic route in the moss Physicomitrium patens. 
    The Plant Journal, 107: 1724-1738, 2021 Sep. DOI: doi.org/10.1111/tpj.15413
    →解説記事
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  13. 石川孝博*（総説）
    微細藻類ユーグレナにおける貯蔵物質パラミロンとワックスエステルの代謝
    生物工学会誌，99：pp408-411，2021年8月．DOI: doi.org/10.34565/seibutsukogaku.99.8_408
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  14. Kameoka T†, Okayasu T†, Kikuraku K, Ogawa T, Sawa Y, Yamamoto H, Ishikawa T and Maruta T* (Original Article)
    Cooperation of chloroplast ascorbate peroxidases and proton gradient regulation 5 is critical for protecting Arabidopsis plants from photooxidative stress.
    The Plant Journal, 107: 876-892, 2021 Aug. DOI: doi.org/10.1111/tpj.15352
    →解説記事
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  15. 石川孝博*，重岡 成（辞典）
    2.9. ビタミンC (2.9.3 生化学・生理学（生合成と輸送）)
    ビタミン・バイオファクター総合辞典（日本ビタミン学会編集, ISBN978-4-254-10292-5），朝倉書店，東京，pp271-274，2021年7月．
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  16. Tamaki S, Tanno Y, Kato S, Ozasa K, Wakazaki M, Sato M, Toyooka K, Maoka T, Ishikawa T, Maeda M, Shinomura T* (Original Article)
    Carotenoid accumulation in the eyespot apparatus required for phototaxis is independent of chloroplast development in Euglena gracilis.

    Plant Science, 298: 110564, 2020 Sep. DOI: doi.org/10.1016/j.plantsci.2020.110564
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  17. 石川孝博*（ミニレビュー）
    植物のアスコルビン酸生合成研究の現状.
    ビタミン，94：438-442，2020年8月．DOI: doi.org/10.20632/vso.94.8_438
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  18. Terai Y, Ueno H, Ogawa T, Sawa Y, Miyagi A, Kawai-Yamada M, Ishikawa T and Maruta T* (Original Article)
    Dehydroascorbate reductases and glutathione set a threshold for high-light-induced ascorbate accumulation.
    Plant Physiology, 183: 112-122, 2020 May. DOI: doi.org/10.1104/pp.19.01556
    →Plant Physiology誌のNews and Viewsで取り上げられました
    →解説記事
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  19. Tamaki S, Nishino K, Ogawa, T, Maruta T, Sawa Y, Arakawa K and Ishikawa T* (Original Article)
    Comparative proteomic analysis of mitochondria isolated from Euglena gracilis under aerobic and hypoxic conditions. 
    PLoS One, 14: e0227226, 2019 Dec. DOI: doi.org/10.1371/journal.pone.0227226
    →解説記事
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  20. Shiroma S, Tanaka M, Sasaki T, Ogawa T, Yoshimura K, Sawa Y, Maruta T* and Ishikawa T (Original Article)
    Chloroplast development activates the expression of ascorbate biosynthesis-associated genes in Arabidopsis roots. 
    Plant Science, 284: 185-191, 2019 Jul. DOI: doi.org/10.1016/j.plantsci.2019.04.012
    →解説記事
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  21. Tamaki S, Kato S, Shinomura T, Ishikawa T and Imaishi H*
    Physiological role of β-carotene monohydroxylase (CYP97H1) in carotenoid biosynthesis in Euglena gracilis. 

    Plant Science, 278: 80-87, 2019 Jan. DOI: doi.org/10.1016/j.plantsci.2018.10.017
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  22. Tomiyama T†, Goto K†, Tanaka Y, Maruta T, Ogawa T, Sawa Y, Ito T and Ishikawa T* (Original Article)
    A major isoform of mitochondrial trans-2-enoyl-CoA reductase is dispensable for wax ester production in Euglena gracilis under anaerobic conditions. 
    PLoS One, 14:e0210755, 2019 Jan. DOI: doi.org/10.1371/journal.pone.0210755
    →解説記事
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  23. Shibata S, Arimura SI, Ishikawa T and Awai K*
    Alterations of Membrane Lipid Content Correlated With Chloroplast and Mitochondria Development in Euglena gracilis.

    Frontiers in Plant Science, 9: 370, 2018 Mar. DOI: doi.org/10.3389/fpls.2018.00370
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  24. Iwaoka Y, Nishino K, Ishikawa T, Ito H, Sawa Y and Tai A* (Original Article)
    Affinity resins as new tools for identifying target proteins of ascorbic acid.
    Analyst, 143: 874-882, 2018 Feb. DOI: doi.org/10.1039/C7AN01592E
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  25. Azad AK*, Ahmed J, Alum MA, Hasan MM, Ishikawa T and Sawa Y (Original Article)
    Prediction of arsenic and antimony transporter major intrinsic proteins from the genomes of crop plants.
    International Journal of Biological Macromolecules, 107: 2630-2642, 2018 Feb. DOI: doi.org/10.1016/j.ijbiomac.2017.10.15
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  26. Kimura M and Ishikawa T* (Original Article)
    Suppression of DYRK orthologs expression affects wax ester fermentation in Euglena gracilis.
    Journal of Applied Phycology, 30: 367-373, 2018 Feb. DOI: doi.org/10.1007/s10811-017-1235-y
    →解説記事
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  27. Ishikawa T*, Maruta T, Yoshimura K and Smirnoff N  (Book chapter)
    Biosynthesis and regulation of ascorbic acid in plants. 
    In: Gupta DE, Palma JM, Corpas FJ, Editors. Antioxidants and Antioxidant enzymes in higher plants. Springer International Publishing, pp163-179, 2018 Mar. DOI: doi.org/10.1007/978-3-319-75088-0_8
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  28. Maruta T* and Ishikawa T (Book chapter)
    Ascorbate peroxidase functions in higher plants: The control of the balance between oxidative damage and signaling. 
    In: Gupta DE, Palma JM, Corpas FJ, Editors. Antioxidants and Antioxidant enzymes in higher plants. Springer International Publishing, pp41-59, 2018 Mar. DOI: doi.org/10.1007/978-3-319-75088-0_3
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  29. Maruta T and Ishikawa T* (Book chapter)
    Ascorbate peroxidases: Crucial roles of antioxidant enzymes in plant stress responses. 
    In: Hossain MA, Munné- Bosch S, Burritt DJ, Vivancos PD, Fujita M, Lorence A, Editors. Ascorbic Acid in Plant Growth, Development and Stress Tolerance. Springer International Publishing, pp111-127, 2018 Mar. DOI: doi.org/10.1007/978-3-319-74057-7_4
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  30. Yoshimura K* and Ishikawa T (Book chapter)
    Chemistry and metabolism of ascorbic acid in plants.
    In: Hossain MA, Munné- Bosch S, Burritt DJ, Vivancos PD, Fujita M, Lorence A, Editors. Ascorbic Acid in Plant Growth, Development and Stress Tolerance. Springer International Publishing, pp1-23, 2018 Mar. DOI: doi.org/10.1007/978-3-319-74057-7_1
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  31. Tomiyama T, Kurihara K, Ogawa T, Maruta T, Ogawa T, Ohta D, Sawa Y and Ishikawa T* (Original Article)
    Wax ester synthase/diacylglycerol acyltransferase isoenzymes play a pivotal role in wax ester biosynthesis in Euglena gracilis. 
    Scientific Reports, 7: 13504, 2017 Oct. DOI: doi.org/10.1038/s41598-017-14077-6
    →解説記事
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  32. Kato S, Soshino M, Takaichi S, Ishikawa T, Nagata N, Asahina M and Shinomura T* (Original Article)
    Suppression of the phytoene synthase gene (EgcrtB) alters carotenoid content and intracellular structure of Euglena gracilis.
    BMC Plant Biology,  17: 125, 2017 Jul. DOI: doi.org/10.1186/s12870-017-1066-7
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  33. Nakazawa M*, Hayashi R, Takenaka S, Inui H, Ishikawa T, Ueda M, Sakamoto T, Nakano Y and Miyatake K (Original Article)
    Physiological functions of pyruvate:NADP+ oxidoreductase and 2-oxoglutarate decarboxylase in Euglena gracilis under aerobic and anaerobic conditions.
    Bioscience, Biotechnology, and Biochemistry, 81: 1386-1393, 2017 Jul. DOI: doi.org/10.1080/09168451.2017.131869
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  34. Tanaka Y, Ogawa T, Maruta T, Yoshida Y, Arakawa K and Ishikawa T* (Original Article)
    Glucan synthase-like 2 is indispensable for paramylon synthesis in Euglena gracilis. 
    FEBS Letters, 591: 1360-1370, 2017 May. DOI: doi.org/10.1002/1873-3468.12659
    →解説記事
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  35. Bito T, Misaki T, Yabuta Y, Ishikawa T, Kawano T and Watanabe F* (Original Article)
    Vitamin B12 deficiency results in severe oxidative stress, leading to memory retention impairment in Caenorhabditis elegans.
    Redox Biology, 11: 21-29, 2017 Apr. DOI: doi.org/10.1016/j.redox.2016.10.01
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  36. Inui H*, Ishikawa T and Tamoi M (Book chapter)
    Wax Ester Fermentation and Its Application for Biofuel Production. 
    In: Schwartzbach SD and Shigeoka S, Editors. Euglena: Biochemistry Cell and Molecular Biology. Springer International Publishing, pp269-283, 2017 Apr. DOI: doi.org/10.1007/978-3-319-54910-1_13
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  37. Ishikawa T*, Tamaki S, Maruta T and Shigeoka S (Book chapter)
    Biochemistry and physiology of reactive oxygen species in Euglena. 
    In: Schwartzbach SD and Shigeoka S, Editors. Euglena: Biochemistry Cell and Molecular Biology. Springer International Publishing, pp47-64, 2017 Apr. DOI: doi.org/10.1007/978-3-319-54910-1_4
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  38. Ozasa K*, Won J, Song S, Tamaki S, Ishikawa T and Maeda M (Original Article)
    Temporal change of photophobic step-up responses of Euglena gracilis investigated through motion analysis. 
    PLoS One, 12: e0172813, 2017 Feb. DOI: doi.org/10.1371/journal.pone.017281
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  39. Azad AK*, Ahmed J, Alum MA, Hasan MM, Ishikawa T, Sawa Y and Katsuhara M (Original Article)
    Genome-Wide Characterization of Major Intrinsic Proteins in Four Grass Plants and Their Non-Aqua Transport Selectivity Profiles with Comparative Perspective.
    PLoS One, 11: e0157735, 2016 Jun. DOI: doi.org/10.1371/journal.pone.015773
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  40. Yamada K, Kazama Y, Mitra S, Marukawa Y, Arashida R, Abe T, Ishikawa T, Suzuki K* (Original Article)
    Production of a thermal stress resistant mutant Euglena gracilis strain using Fe-ion beam irradiation.
    Bioscience, Biotechnology, and Biochemistry, 80: 1650-1656, 2016 Aug. DOI: doi.org/10.1080/09168451.2016.117170
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  41. Ishikawa T*, Maruta T, Ogawa T, Yoshimura K and Shigeoka S (Book chapter)
    Redox balance in chloroplasts as a modulator of environmental stress responses: the role of ascorbate peroxidase and nudix hydrolase in Arabidopsis. 
    In: Gupta DE, Palma JM, Corpas FJ, Editors. Redox State as a Central Regulator of Plant-Cell Stress Responses. Springer International Publishing, pp51-70, 2016 Sep. DOI: doi.org/10.1007/978-3-319-44081-1_3
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  42. Maruta T, Sawa Y, Shigeoka S and Ishikawa T* (Mini review)
    Diversity and evolution of ascorbate peroxidase functions in chloroplasts: more than just a classical antioxidant enzyme? 
    Plant & Cell Physiology, 57: 1377-1386, 2016 Jul. DOI: doi.org/10.1093/pcp/pcv203
    →解説記事
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  43. Yoshida Y, Tomiyama T, Maruta T, Tomita M, Ishikawa T* and Arakawa K (Original Article)
    De novo assembly and comparative transcriptome analysis of Euglena gracilis in response to anaerobic conditions. 
    BMC Genomics, 17: 182, 2016 Mar. DOI: doi.org/10.1186/s12864-016-2540-6
    →解説記事
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  44. Kato S, Takaichi S, Ishikawa T, Asahina M, Takahashi S and Shinomura T (Original Article)
    Identification and functional analysis of the geranylgeranyl pyrophosphate synthase gene (crtE) and phytoene synthase gene (crtB) for carotenoid biosynthesis in Euglena gracilis.
    BMC Plant Biol., 5;16:4, 2016 Jan.
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  45. Ogawa T, Kimura A, Sakuyama H, Tamoi M, Ishikawa T and Shigeoka S (Original Article)
    Identification and characterization of cytosolic fructose-1,6-bisphosphatase in Euglena gracilis.
    Bioscience, Biotechnology, and Biochemistry, 79: 1957-1964, 2015 Dec.
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  46. Suzuki K, Mitra S, Iwata O, Ishikawa T, Kato S and Yamada K (Original Article)
    Selection and characterization of Euglena anabaena var. minor as a new candidate Euglena species for industrial application.
    Bioscience, Biotechnology, and Biochemistry, 79: 1730-1736, 2015 Oct.
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  47. Takeda T, Nakano Y, Takahashi M, Konno N, Sakamoto Y, Arashida R, Marukawa Y, Yoshida E, Ishikawa T and Suzuki K (Original Article)
    Identification and enzymatic characterization of an endo-1,3-β-glucanase from Euglena gracilis.
    Phytochemistry, 2015 Aug;116:21-7.
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  48. Tamaki S, Maruta T, Sawa Y, Shigeoka S and Ishikawa T* (Original Article)
    Biochemical and physiological analyses of NADPH-dependent thioredoxin reductase isozymes in Euglena gracilis. 
    Plant Science, 236: 29-36, 2015 Jul. DOI: doi.org/10.1016/j.plantsci.2015.03.016
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  49. Ogawa T, Kimura A, Sakuyama H, Tamoi M, Ishikawa T and Shigeoka S (Original Article)
    Characterization and physiological role of two types of chloroplastic fructose-1,6-bisphosphatases in Euglena gracilis.
    Arch. Biochem. Biophys., 575: 61-68, 2015 Jun.
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  50. Ogawa T, Tamoi M*, Kimura A, Mine A, Sakuyama H, Yoshida E, Maruta T, Suzuki K, Ishikawa T and Shigeoka S (Original Article)
    Enhancement of photosynthetic capacity in Euglena gracilis by expression of cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphosphatase leads to increases in biomass and wax ester production. 
    Biotechnology for Biofuels, 8: 80, 2015 May. DOI: doi.org/10.1186/s13068-015-0264-5
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  51. Wheeler G, Ishikawa T, Pornsaksit V and Smirnoff N (Original Article)
    Evolution of alternative biosynthetic pathways for vitamin C following plastid acquisition in photosynthetic eukaryotes.
    eLIFE, 13: 4, 2015 Mar (doi: 10.7554/eLife.06369).
    →解説
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  52. Tanaka H, Maruta T, Tamoi M, Yabuta Y, Yoshimura K, Ishikawa T and Shigeoka S* (Original Article)
    Transcriptional control of vitamin C defective 2 and tocopherol cyclase genes by light and plastid-derived signals: the partial involvement of GENOMES UNCOUPLED 1. 
    Plant Science, 231: 20-29, 2015 Feb. DOI: doi.org/10.1016/j.plantsci.2014.11.007
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  53. Tamaki S, Maruta T, Sawa Y, Shigeoka S and Ishikawa T* (Original Article)
    Identification and functional analysis of peroxiredoxin isoforms in Euglena gracilis. 
    Bioscience, Biotechnology, and Biochemistry, 78: 593-601, 2014 Apr. DOI: doi.org/10.1080/09168451.2014.890037
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  54. Maruta T†, Noshi M†, Nakamura M, Matsuda S, Tamoi M, Ishikawa T and Shigeoka S* (Original Article)
    Ferulic acid 5-hydroxylase 1 is essential for expression of anthocyanin biosynthesis-associated genes and anthocyanin accumulation under photooxidative stress in Arabidopsis. 
    Plant Science, 219-220: 61-68, 2014 Apr. DOI: doi.org/10.1016/j.plantsci.2014.01.003
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  55. Yoshimura K*, Nakane T, Kume S, Shiomi Y, Maruta T, Ishikawa T and Shigeoka S (Original Article)
    Transient expression analysis revealed the importance of VTC2 expression level in light/dark regulation of ascorbate biosynthesis in Arabidopsis. 
    Bioscience, Biotechnology, and Biochemistry, 78: 60-66, 2014 Jan. DOI: doi.org/10.1080/09168451.2014.877831
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  56. Maruta T, Ojiri M, Noshi M, Tamoi M, Ishikawa T and Shigeoka S* (Original Article)
    Activation of γ-aminobutyrate production by chloroplastic H2O2 is associated with the oxidative stress response. 
    Bioscience, Biotechnology, and Biochemistry, 77: 422-425, 2013 Feb. DOI: doi.org/10.1271/bbb.120825
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  57. Azad AK, Hanawa R, Ishikawa T, Sawa Y and Shibata H (Original Article)
    Expression profiles of aquaporin homologues and petal movement during petal development in Tulipa gesneriana.
    Physiol. Plant., 148: 397-407, 2013 Jul.
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  58. Maruta T, Inoue T, Noshi M, Tamoi M, Yabuta Y, Yoshimura K, Ishikawa T and Shigeoka S* (Original Article)
    Cytosolic ascorbate peroxidase 1 protects organelles against oxidative stress by wounding- and jasmonate-induced H2O2 in Arabidopsis plants. 
    Biochimica et Biophysica Acta - General Subjects, 1820: 1901-1907, 2012 Dec. DOI: doi.org/10.1016/j.bbagen.2012.08.003
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  59. 石川孝博，重岡成
    1-2-1-14. ビタミン.
    藻類ハンドブック（渡邉　信 監修， ISBN978-4-86469-002-7），NTS，東京，pp218-222 (2012年7月)
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  60. Maruta T, Noshi M, Tanouchi A, Tamoi M, Yabuta Y, Yoshimura K, Ishikawa T and Shigeoka S* (Original Article)
    H2O2-triggered retrograde signaling from chloroplasts to nucleus plays specific role in response to stress. 
    Journal of Biological Chemistry, 287: 11717-11729, 2012 Apr. DOI: doi.org/10.1074/jbc.M111.292847
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  61. Gao Y, Badejo AA, Sawa Y and Ishikawa T (Original Article)
    Analysis of two L-galactono-1,4-lactone responsive genes with complementary expression during the development of Arabidopsis thaliana.
    Plant Cell Physiol., 53: 592-601, 2012 Mar.
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  62. Badejo AA, Wada K, Gao Y, Maruta T, Sawa Y, Shigeoka S and Ishikawa T* (Original Article)
    Translocation and the alternative D-galacturonate pathway contribute to increasing the ascorbate level in ripening tomato fruits together with the D-mannose/L-galactose pathway. 
    Journal of Experimental Botany, 63: 229-239, 2012 Jan. DOI: doi.org/10.1093/jxb/err275
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  63. Gao Y, Badejo AA, Shibata H, Sawa Y, Maruta T, Shigeoka S, Page M, Smirnoff N and Ishikawa T* (Original Article)
    Expression analysis of the VTC2 and VTC5 genes encoding GDP-L-galactose phosphorylase, an enzyme involved in ascorbate biosynthesis in Arabidopsis thaliana.
    Bioscience, Biotechnology, and Biochemistry, 75: 1783-1788, 2011 Sep. DOI: doi.org/10.1271/bbb.110320
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  64. 石川孝博（総説）
    光合成生物におけるアスコルビン酸生合成研究の新展開.
    生化学，83巻，pp838-841，2011年9月
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  65. Gao Y, Nishikawa H, Badejo AA, Shibata H, Sawa Y, Nakagawa T, Maruta T, Shigeoka S, Smirnoff N and Ishikawa T* (Original Article)
    Expression of aspartyl protease and C3HC4-type RING zinc finger genes are responsive to ascorbic acid in Arabidopsis thaliana. 
    Journal of Experimental Botany, 62: 3647-3657, 2011 Jun. DOI: doi.org/10.1093/jxb/err068
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  66. Maruta T, Inoue T, Tamoi M, Yabuta Y, Yoshimura K, Ishikawa T and Shigeoka S* (Original Article)
    Arabidopsis NADPH oxidases, AtrbohD and AtrbohF, are essential for jasmonic acid-induced expression of genes regulated by MYC2 transcription factor. 
    Plant Science, 180: 655–660, 2011 Apr. DOI: doi.org/10.1016/j.plantsci.2011.01.014
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  67. 石川孝博，重岡成（辞典）
    II 9. ビタミンC (9.2.2 生合成経路と酸化還元系)
    ビタミン総合辞典（日本ビタミン学会　編集, ISBN978-4-254-10228-4），朝倉書店，東京，pp395-398 (2010年11月)
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  68. Ishikawa T, Tajima N, Nishikawa H, Gao Y, Rapolu M, Shibata H, Sawa Y and Shigeoka S (Original Article)
    Euglena gracilis ascorbate peroxidase forms an intramolecular dimeric structure: its unique molecular characterization.
    Biochem. J., 426: 125-134, 2010 Feb.
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  69. Maruta T, Ichikawa Y, Mieda T, Takeda T, Tamoi M, Yabuta Y, Ishikawa T and Shigeoka S* (Original Article)
    The contribution of Arabidopsis homologs of L-gulono-1,4-lactone oxidase to the biosynthesis of ascorbic acid. 
    Bioscience, Biotechnology, and Biochemistry, 74: 1494-1497, 2010 Jul. DOI: doi.org/10.1271/bbb.100157
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  70. Maruta T, Tanouchi A, Tamoi M, Yabuta Y, Yoshimura K, Ishikawa T and Shigeoka S* (Original Article)
    Arabidopsis chloroplastic ascorbate peroxidase isoenzymes play a dual Role in photoprotection and gene regulation under photooxidative stress. 
    Plant & Cell Physiology, 51:190-200, 2010 Feb. DOI: doi.org/10.1093/pcp/pcp177
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  71. Ishikawa T, Nishikawa H, Gao Y, Sawa Y, Shibata H, Yabuta Y, Maruta T and Shigeoka S (Original Article)
    The pathway via D-galacturonate/L-galactonate is significant for ascorbate biosynthesis in Euglena gracilis: identification and functional characterization of aldonolactonase.
    J. Biol. Chem., 283: 31133-31141, 2008 Nov.
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  72. Yabuta Y, Maruta T, Nakamura A, Mieda T, Yoshimura, Ishikawa T and Shigeoka S* (Original Article)
    Conversion of L-galactono-1,4-lactone to L-ascorbate is regulated by the photosynthetic electron transport chain in Arabidopsis. 
    Bioscience, Biotechnology, and Biochemistry, 72: 2598-2607, 2008 Oct. DOI: doi.org/10.1271/bbb.80284
    - - -
  73. Maruta T, Yonemitsu M, Yabuta Y,Tamoi M, Ishikawa T and Shigeoka S* (Original Article)
    Arabidopsis phosphomannose isomerase 1, but not phosphomannose isomerase 2, is essential for ascorbic acid biosynthesis. 
    Journal of Biological Chemistry, 283: 28842-28851, 2008 Oct. DOI: doi.org/10.1074/jbc.M805538200
    - - -
  74. Ishikawa T and Shigeoka S (Review)
    Recent advances in ascorbate biosynthesis and the physiological significance of ascorbate peroxidase in photosynthesizing organisms.
    Biosci. Biotechnol. Biochem., 72: 1143-1154, 2008 May.
    - - -
  75. Dowdle J, Ishikawa T, Gatzek S, Rolinski S and Smirnoff N (Original Article)
    Two genes in Arabidopsis thaliana encoding GDP-L-galactose phosphorylase are required for ascorbate biosynthesis and seedling viability.
    Plant J. 52: 673-689, 2007 Sep.
    - - -
  76. Yabuta Y†, Mieda T†, Rapolu M, Nakamura A, Motoki T, Maruta T, Yoshimura K, Ishikawa T and Shigeoka S* (Original Article)
    Light regulation of ascorbate biosynthesis is dependent on the photosynthetic electron transport chain but independent of sugars in Arabidopsis. 
    Journal of Experimental Botany, 58: 2661-2671, 2007 Jun. DOI: doi.org/10.1093/jxb/erm124
    - - -
  77. 吉村和也、薮田行哲、石川孝博、重岡　成（総説）
    レドックス制御に関わるアスコルビン酸およびヌクレオシド二リン酸類縁体(Nudix).
    ビタミン，81巻，83-93，2007年3月
    - - -
  78. 石川孝博，重岡成（総説）
    原生動物ユーグレナ.
    光合成微生物の機能と応用（上原赫　監修, ISBN: 4-88231-596-3）， シーエムシー出版，東京，pp125-137 (2006年12月)
    - - -
  79. Ishikawa T, Masumoto I, Iwasa N, Nishikawa H, Sawa Y, Shibata H, Nakamura A, Yabuta Y and Shigeoka S (Original Article)
    Functional characterization of D-galacturonic acid reductase, a key enzyme of the ascorbate biosynthesis pathway, from Euglena gracilis.
    Biosci. Biotech. Biochem., 70:2720-2726, 2006 Nov.
    - - -
  80. Ishikawa T, Dowdle J and Smirnoff N (Review)
    Progress in manipulating ascorbic acid biosynthesis and accumulation in plants.
    Physiol. Plant., 126: 343-355, 2006 Feb.
    - - -
  81. Ishikawa T, Morimoto Y, Rapolu M, Sawa Y, Shibata H, Yabuta Y, Nishizawa A and Shigeoka S (Original Article)
    Acclimation to diverse environmental stresses caused by a suppression of cytosolic ascorbate peroxidase in tobacco BY-2 cells.
    Plant Cell Physiol., 46: 1264-1271, 2005 Aug.
    - - -
  82. Yabuta Y, Maruta T, Yoshimura K, Ishikawa T and Shigeoka S* (Original Article)
    Two distinct redox signaling pathways for cytosolic APX induction under photooxidative stress. 
    Plant & Cell Physiology, 45: 1586-1594, 2004 Nov. DOI: doi.org/10.1093/pcp/pch181
    - - -
  83. 石川孝博、重岡成（総説）
    酸化ストレス防御の環境適応機構.
    遺伝，58巻，pp49-55，2004年11月
    - - -
  84. Mieda T, Yabuta Y, Rapolu M, Motoki T, Takeda T, Yoshimura K, Ishikawa T and Shigeoka S (Original Article)
    Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate.
    Plant Cell Physiol., 45: 1271-1279, 2004 Sep.
    - - -
  85. 石川孝博（総説）
    アスコルビン酸ペルオキシダーゼの発現調節と活性酸素代謝．
    日本農芸化学会誌，78巻，pp.962-964，2004.
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  86. Ishikawa T, Madhusudhan R and Shigeoka S (Original Article)
    Effect of iron on the expression of ascorbate peroxidase in Euglena gracilis.
    Plant Sci    ., 165: 1363-1376, 2003 Dec.
    - - -
  87. Wada K, Tada T, Nakamura Y, Ishikawa T, Yabuta Y, Yoshimura K, Shigeoka S and Nishimura K (Original Article)
    Crystal structure of chloroplastic ascorbate peroxidase from tobacco plants and structural insights into its instability.
    J. Biochem., 134: 239-244, 2003 Aug.
    - - -
  88. Madhusudhan R, Ishikawa T, Sawa Y, Shigeoka S and Shibata H (Original Article)
    Post-transcritional regulation of ascorbate peroxidase during light adaptation of Euglena gracilis.
    Plant Sci., 165: 233-238, 2003 Jul.
    - - -
  89. Madhusudhan R, Ishikawa T, Sawa Y, Shigeoka S and Shibata H (Original Article)
    Characterization of an ascorbate peroxidase in plastids of tobacco BY-2 cells.
    Physiol. Plant.,     117: 550-557, 2003.
    - - -
  90. 石川孝博, 藪田行哲, 田茂井政宏, 重岡　成（総説）
    レドックスと代謝エンジニアリング.
    蛋白質・核酸・酵素，48: 2145-2153，2003.
    - - -
  91. 重岡成, 吉村和也, 石川孝博（総説）
    植物はなぜビタミンCを多く含むのか？―光・酸素毒防御系への関与―.
    ビタミン，77巻，pp363-375，2003.
    - - -
  92. 石川孝博（総説）
    高等植物における抗酸化酵素の転写後調節機構とストレス耐性獲得への利用.
    日本農芸化学会誌，77巻，pp. 494-497，2003.
    - - -
  93. Kashiba M, Oka J, Ichikawa R, Kasahara E, Inayama T, Kageyama A, Kageyama H, Osaka T, Umegaki K, Matsumoto A, Ishikawa T, Nishikimi M, Inoue M and Inoue S (Original Article)
    Impaired ascorbic acid metabolism in streptozotocin-induced diabetic rats.
    Free Radic. Biol. Med., 33: 1221-1230, 2002.
    - - -
  94. Yabuta Y, Motoki T, Yoshimura K, Takeda T, Ishikawa T and Shigeoka S (Original Article)
    Thylakoid-membrane bound ascorbate peroxidase is a limiting factor of antioxidative systems under photooxidative stress.
    Plant J., 32: 915-925, 2002.
    - - -
  95. Yoshimura K, Yabuta Y, Ishikawa T and Shigeoka S (Original Article)
    Identification of a cis-element for tissue-specific alternative splicing of chloroplast ascorbate peroxidase in higer plants.
    J. Biol. Chem., 277: 40623-40632, 2002.
    - - -
  96. Shigeoka S, Ishikawa T, Tamoi M, Miyagawa Y, Takeda T, Yabuta Y and Yoshimura K (Review)
    Regulation and function of ascorbate peroxidase isoenzymes.
    J. Exp. Bot., 53: 1305-1319, 2002 May.
    - - -
  97. Yoshimura K, Ishikawa T, Wada K, Takeda T, Kamata Y, Tada T, Nishimura K, Nakano Y and Shigeoka S (Original Article)
    Characterization of monoclonal antibodies against ascorbate peroxidase isoenzymes: purification and epitope-mapping using immunoaffinity column chromatography.
    Biochim. Biophys. Acta, 1526:168-174, 2001.
    - - -
  98. 石川孝博、吉村和也（総説）
    光合成生物の酸化ストレス防御系.
    生物工学，79巻，pp. 307-311，2001.
    - - -
  99. Kashiba M, Oka J, Ichikawa R, Kageyama A, Inayama T, Kageyama H, Ishikawa T, Nishikimi M, Inoue M and Inoue S (Original Article)
    Impaired reductive regeneration of ascorbic acid in the Goto-Kakizaki diabetic rat.
    Biochem. J., 351: 313-318, 2000.
    - - -
  100. Yoshimura K, Yabuta Y, Ishikawa T and Shigeoka S (Original Article)
    Expression of spinach ascorbate peroxidase isoenzymes in response to oxidative stress.
    Plant Physiol., 123: 223-233, 2000.
    - - -
  101. Yoshimura K, Yabuta Y, Tamoi M, Ishikawa T and Shigeoka S (Original Article)
    Alternative spliced mRNA variants of chloroplast ascorbate peroxidase isoenzymes in spinach leaves.
    Biochem J.    , 338: 41-48, 1999.
    - - -
  102. 吉村和也、石川孝博、重岡成（総説）
    葉緑体アスコルビン酸ペルオキシダーゼ合成の巧みなメカニズム.
    化学と生物，37巻，pp. 833-838，1999.
    - - -
  103. 重岡成、石川孝博、武田徹、田茂井政宏（総説）
    光合成生物における光・酸素毒防御系の分子機構 -光・酸素毒耐性植物の創製は可能か-
    蛋白質・核酸・酵素，43巻，pp. 634-648，1998.
    - - -
  104. Ishikawa T, Casini AF and Nishikimi M (Original Article)
    Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reductase.
    J. Biol. Chem., 273: 28708-28712, 1998
    - - -
  105. Takeda T, Yoshimura K, Ishikawa T and Shigeoka S (Original Article)
    Purification and characterization of ascorbate peroxidase in Chlorella vulgaris.
    Biochimie, 80: 295-301, 1998.
    - - -
  106. Nishikimi M, Ohta Y and Ishikawa T (Original Article)
    Identification by bacterial expression of the yeast genomic sequence encoding L-galactono-g-lactone oxidase, the homologue of L-ascorbic acid-synthesizing enzyme of higher animals.
    Biochem. Mol. Biol. Int., 44: 907-913, 1998.
    - - -
  107. Yoshimura K, Ishikawa T, Nakamura Y, Tamoi M, Takeda T, Tada T, Nishimura K and Shigeoka S (Original Article)
    Comparative study on recombinant chloroplastic and cytosolic ascorbate peroxidase isozymes of spinach.
    Arch. Biochem. Biophys., 353: 55-63, 1998.
    - - -
  108. Ishikawa T, Ohta Y, Takeda T, Shigeoka S and Nishikimi M (Original Article)
    Increased cellular resistance to oxidative stress by expression of cyanobacterium catalase-peroxidase in animal cells.
    FEBS Lett., 426: 221-224, 1998.
    - - -
  109. Ishikawa T, Yoshimura K, Sakai K, Tamoi M, Takeda T and Shigeoka S (Original Article)
    Molecular characterization and physiological role of a glyoxysome-bound ascorbate peroxidase from spinach.
    Plant Cell Physiol    ., 39: 23-34, 1998.
    - - -
  110. Nishikawa T, Lee-Matsui IS, Shiraishi N, Ishikawa T, Ohta Y and Nishikimi M (Original Article)
    Identification of S100b protein as copper-binding protein and its suppression of copper-induced cell damage.
    J. Biol. Chem., 272: 23037-23041, 1997.
    - - -
  111. Takeda T, Ishikawa T and Shigeoka S (Original Article)
    Metabolism of hydrogen peroxide by the scavenging system in Chlamydomonas reinhardtii.
    Physiol. Plant., 99: 49-55., 1997.
    - - -
  112. Ishikawa T, Yoshimura K, Tamoi M, Takeda T and Shigeoka S (Original Article)
    Alternative mRNA splicing of 3′-terminal exons generates ascorbate peroxidase isoenzymes in spinach (Spinacia oleracea) chloroplasts.
    Biochem. J.    , 328: 795-800, 1997.
    - - -
  113. Tamoi M, Ishikawa T, Takeda T and Shigeoka S (Original Article)
    Molecular characterizationand resistance to hydrogen peroxide of two fructose-1,6-bisphosphatases from Synechococcus PCC 7942.
    Arch. Biochem. Biophys., 334: 27-36, 1996.
    - - -
  114. Tamoi M, Ishikawa T, Takeda T and Shigeoka S (Original Article)
    Enzymic and molecular characterization of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase from Synechococcus PCC 7942: resistance of the enzyme to hydrogen peroxide.
    Biochem. J    ., 316: 685-690, 1996.
    - - -
  115. Mutsuda M, Ishikawa T, Takeda T and Shigeoka S (Original Article)
    The catalase-peroxidase of Synechococcus PCC 7942: purification, nucleotide sequence analysis and expression in Escherichia coli.
    Biochem. J., 316: 251-257, 1996.
    - - -
  116. Ishikawa T, Takeda T and Shigeoka S (Original Article)
    Purification and characterization of cytosolic ascorbate peroxidase from komatsuna (Brassica rapa).
    Plant Sci., 120: 11-18, 1996.
    - - -
  117. Ishikawa T, Takeda T, Kohno H and Shigeoka S (Original Article)
    Molecular characterization of Euglena ascorbate peroxidase using monoclonal antibody.
    Biochim. Biophys. Acta, 1290: 69-75, 1996.
    - - -
  118. Ishikawa T, Sakai K, Yoshimura K, Takeda T and Shigeoka S (Original Article)
    cDNAs encoding spinach stromal and thylakoid-bound ascorbate peroxidase, differing in the presence or absence of their 3′-coding regions.
    FEBS Lett    ., 384: 289-293, 1996.
    - - -
  119. Mutsuda M, Ishikawa T, Takeda T and Shigeoka S (Original Article)
    Subcellular localization and properties of L-galactono-g-lactone dehydrogenase in spinach leaves.
    Biosci. Biotech. Biochem., 59: 1983-1984, 1995.
    - - -
  120. Ishikawa T, Sakai K, Takeda T and Shigeoka S (Original Article)
    Cloning and expression of cDNA encoding a new type of ascorbate peroxidase from spinach.
    FEBS Lett., 367: 28-32, 1995.
    - - -
  121. Takeda T, Ishikawa T, Shigeoka S, Hirayama O and Mitsunaga T (Original Article)
    Purification and characterization of glutathione reductase from Chlamydomonas reinhardtii.
    J. Gen. Microbiol., 139: 2233-2238, 1993.
    - - -
  122. Ishikawa T, Takeda T, Shigeoka S, Hirayama O and Mitsunaga T (Original Article)
    Requirement for iron and its effect on ascorbate peroxidase in Euglena gracilis.
    Plant Sci., 93: 25-29, 1993.
    - - -
  123. Ishikawa T, Takeda T, Shigeoka S, Hirayama O and Mitsunaga T (Original Article)
    Hydrogen peroxide generation in organelles of Euglena gracilis.
    Phytochemistry, 1993, 33: 1297-1299.